Ipsen (Euronext : IPN ; ADR : IPSEY), groupe pharmaceutique de spécialité international, a annoncé aujourd’hui que Somatuline® Autogel® (lanréotide), le télotristat éthyl, ainsi que la molécule expérimentale 177Lu-OPS201, font l’objet de 23 présentations lors de la conférence 2017 de la European Neuroendocrine Tumor Society (ENETS).
Le Docteur Sotirios Stergiopoulos, Vice-Président Sénior, Head of Global Medical Affairs, Ipsen a déclaré : « Nous sommes très heureux de participer à cette conference et de présenter les données concernant le lanréotide, le telotristat ethyl et le 177Lu-OPS201. De plus, Ipsen a soutenu plusieurs projets pour comprendre la biologie, l’épidémiologie, les modalités de traitement et les besoins non satisfaits des patients souffrant de tumeurs neuroendocrines (TNE). Tout ceci démontre l’engagement d’Ipsen à améliorer la vie des patients souffrant de TNE. »
17 présentations sont consacrées au lanréotide (Somatuline® Autogel®) :
ABSTRACTS SÉLECTIONNÉS POUR UNE PRÉSENTATION ORALE
[A10] Krug S et al. Interactions between SSTR Modulation via Lanreotide and Molecular Targeted Therapies in Sequential and Combination Approaches in Vitro. Session : Symposium Jeunes investigateurs ENETS/NANETS
[K12] Martínez-López A et al. Efficacy of Lanreotide (LAN), both Alone and in Combination with Targeted Therapies in a Preclinical Model of Pancreatic Neuroendocrine Tumors (pNETs). Session : 4A – Abstracts en science fondamentale
ABSTRACTS SÉLECTIONNÉS POUR LA PRÉSENTATION DE POSTER
[K17] Phan AT et al. Safety and Tolerability of Lanreotide Autogel/Depot (LAN) in Patients (pts) with Neuroendocrine Tumours (NETs): Pooled Analysis of Clinical Studies
[K18] Phan AT et al. Long-Term Efficacy and Safety with Lanreotide Autogel/Depot (LAN) from CLARINET and Open-Label Extension (OLE) Studies
[K5] Duchateau L et al. An Exploratory Patient Centric Analysis of the ELECT Trial: A Phase 3 Study of Efficacy and Safety of Lanreotide Autogel/Depot (LAN) Treatment for Patients (pts) with Carcinoid Syndrome (CS)
[C5] Meyer T et al. CALM-NET, A Multicentre, Exploratory Study to Assess the Clinical Value of Circulating Tumour Cells (CTCs) Enumeration in Patients (Pts) with Functioning Midgut NETs Receiving Lanreotide Autogel (LAN)
[K1] Albertelli M et al. Safety and Efficacy of High Doses Lanreotide Treatment in Patients with Progressive Neuroendocrine Tumors: Results from a Prospective Phase II Trial. Remarque : il s’agit d’un essai parrainé par l’investigateur.
[K15] Pavel M et al. Safety and Efficacy of 14-Day Dosing Interval of Lanreotide Autogel/Depot (LAN) for Patients with Pancreatic or Midgut Neuroendocrine Tumours (NETs) Progressing on LAN Every 28 Days: The Prospective, Open-label, International, Phase 2 CLARINET FORTE Study
[J8] Lepage C et al. REMINET: A European, Multicenter, Phase II/III Randomized Double-Blind, Placebo-Controlled Study Evaluating Lanreotide As Maintenance Therapy after First-Line Treatment in Patients with Non-Resectable Duodeno-Pancreatic Neuroendocrine Tumors. Remarque : il s’agit d’un essai parrainé par l’investigateur.
[K2] Almquist M et al. STREET – Somatostatin Treatment Experience Trial
[A12] Lelek S et al. Antiproliferative Effects of Lanreotide in Neuroendocrine Tumors. Remarque : il s’agit d’un essai parrainé par l’investigateur.
[K20] Reidy-Lagunes D et al. Lanreotide Autogel/Depot (LAN) in Lung Neuroendocrine Tumours (NETs): The Randomized, Double-Blind, Placebo (PBO)-Controlled, International Phase 3 SPINET Study
[K7] Ferolla P et al. Open-Label Multicentre Single-Arm Phase 2 Trial of Lanreotide Autogel (LAN) in Combination with Temozolomide (TMZ) in Patients with Advanced Well/Moderately Differentiated Neuroendocrine Tumours (NETs) of Lung and Thymus: ATLANT
[K9] Geilvoet W et al. Patient Satisfaction Regarding Home Injection Service for Somatostatin Analogues: A Survey among Patients with a Neuroendocrine Tumour. Remarque : il s’agit d’un essai parrainé par l’investigateur.
[N15] Prasad V et al. Lanreotide Autogel/Depot (LAN) in Combination with Peptide Receptor Radionuclide Therapy (PRRT) in Progressive Digestive and Lung Neuroendocrine Tumours (NETs): Design of the PRELUDE Study
[Q36] van Fraeyenhove F et al. Tumor Growth Rate to Assess Tumor Activity in Patients with Lung Neuroendocrine Tumors on Lanreotide Autogel: A Case-Series Analysis. Remarque : il s’agit d’un essai parrainé par l’investigateur.
[K19] Prinzi N et al. Safety of Lanreotide 120 mg ATG (LAN) in Combination with Metformin (MET) in Patients (pts) with Progressive Advanced Well-Differentiated (WD) Gastro-Intestinal (GI) or Lung Carcinoids. A Pilot, One-Arm, Open-Label, Prospective Study: The MetNET-2 Trial. Remarque : il s’agit d’un essai parrainé par l’investigateur.
Le télotristat éthyl fait l’objet de 5 présentations :
ABSTRACTS SÉLECTIONNÉS POUR LA PRÉSENTATION DE POSTER
[K16] Pavel M et al. Telotristat Ethyl in Carcinoid Syndrome: Safety and Efficacy Results of an Open-Label Extension of the TELECAST Phase 3 Clinical Trial
[L2] Anthony L et al. Impact of Concomitant Medication on Efficacy of Telotristat Ethyl – A Post Hoc Subgroup Analysis of the Phase 3 TELESTAR Study in Carcinoid Syndrome
[L7] Lapuerta P et al. Integrated Safety Analysis of Telotristat Ethyl in Patients with Carcinoid Heart Disease
[M3] Cella D et al. Relationship Between Symptoms and HRQoL Benefits in Patients (pts) with Carcinoid Syndrome (CS): A Post-Hoc Analysis of Telotristat Ethyl (TE) TELESTAR Trial
[M8] Pavel M et al. Correlation of Plasma (p) and Urine (u) 5-HIAA Levels in Patients (pts) with Carcinoid Syndrome (CS) – Post-Hoc Analyses from the TELESTAR Study
177Le Lu-OPS201 fait l’objet d’une présentation :
ABSTRACT SÉLECTIONNÉ POUR LA PRÉSENTATION DE POSTER
[N12] Nicolas G et al. Peptide Receptor Radionuclide Therapy (PRRT) with a Somatostatin Receptor (SSTR) Antagonist in Patients with SSTR-Positive, Progressive Neuroendocrine Tumours (NETs): A Phase I/II Open-Label Trial to Evaluate the Safety and Preliminary Efficacy of 177Lu-OPS201
