Investors

Ipsen has a sponsored Level I American Depositary Receipt (ADR) program in the United States in June 2010 with the trust company Deutsche Bank Americas (Deutsche Bank).

• Ticker: IPSEY
• Structure: Sponsored ADR Level
• Exchange: OTC
• Ratio (ORD:ADR): 1:4
• ISIN ADR: US4626291060
• ORD ISIN: FR0010259150

COORDINATES OF ADR HOLDERS: Deutsche Bank Shareholder Services

Operations Center

6201 15th Avenue

Brooklyn, NY 11219

United States

Email: DB@astfinancial.comNuméro

Toll Free: +1 (866) 706-0509

Direct Dial: +1 (718) 921-8137

The Company’s ADR program is sponsored by Deutsche Bank. As custodian bank, Deutsche Bank performs the following roles for ADR holders:

• Registers and maintains the register of ADR holders
• Is the share transfer agent
• Distributes dividends in U.S. dollars (if applicable)
• Facilitates the proxy voting process and votes on behalf of ADR holders (if applicable)
• Issues and cancels the Issues and cancels Ipsen ADSs (American Depository Shares)
• May distribute company circulars and annual general meeting materials (if applicable)

For holders who are not registered because their shares are held through a “street name” (nominee account), the Company may issue a proxy to the holder of the ADS. name), your nominee will receive materials from Deutsche Bank from time to time for distribution to ADR holders. You should make arrangements with your nominee if you wish to receive these materials and be able to vote through the custodian bank at general meetings (if applicable).